Polyketides from the Deep-Sea-Derived Fungus Graphostroma sp. MCCC 3A00421 Showed Potent Antifood Allergic Activities.
Siwen NiuQingmei LiuJin-Mei XiaChun-Lan XieZhu-Hua LuoZongze ShaoGuang-Ming LiuXian-Wen YangPublished in: Journal of agricultural and food chemistry (2018)
To discover antifood allergic components from deep-sea-derived microorganisms, we performed a systematic chemical investigation of the Atlantic hydrothermal fungus Graphostroma sp. MCCC 3A00421. Consequently, nine new (1-9) and 19 known (10-28) polyketides were isolated. The planar structures of the new compounds were elucidated mainly by detailed analysis of their nuclear magnetic resonance and high-resolution electrospray ionization mass spectrometry data, while the absolute configurations were established using the modified Mosher's method in association with electronic circular dichroism spectra. Graphostrin A (1) is a novel chlorinated polyketide derivate bearing an oxazole moiety. All isolates were tested for antifood allergic bioactivities in immunoglobulin E-mediated rat basophilic leukemia-2H3 cells. Reticulol (10) significantly decreased the rates of degranulation and histamine release with IC50 values of 13.5 and 13.7 μM, respectively, suggesting reticulol could be a potential antifood allergic medicine.
Keyphrases
- high resolution
- mass spectrometry
- magnetic resonance
- allergic rhinitis
- induced apoptosis
- liquid chromatography
- oxidative stress
- electronic health record
- gas chromatography
- bone marrow
- cell cycle arrest
- cell proliferation
- machine learning
- deep learning
- density functional theory
- big data
- computed tomography
- climate change
- signaling pathway
- ms ms
- simultaneous determination