Spatial transcriptomic patterns underlying regional vulnerability to amyloid-β and tau pathologies and their relationships to cognitive dysfunction in Alzheimer's disease.

Meichen Yu Shannon L Risacher Kwangsik T Nho Qiuting Wen Adrian L Oblak Frederick W Unverzagt Liana G Apostolova Martin R Farlow Jared R BroschDavid G ClarkSophia WangRachael Deardorff Yu-Chien Wu Sujuan Gao Olaf Sporns Andrew J Saykinnull null

Published in: medRxiv : the preprint server for health sciences (2023)

We identified replicable cognition-related associations between regional gene expression profiles and selectively regional vulnerability to amyloid-β and tau pathologies in AD.

Keyphrases

climate change
cerebrospinal fluid
cognitive decline
copy number
gene expression
mild cognitive impairment
white matter
dna methylation
transcription factor