Persistent C-peptide secretion in Type 1 diabetes and its relationship to the genetic architecture of diabetes.
Paul M McKeigueAthina SpiliopoulouStuart McGurnaghanMarco ColomboLuke BlackbournTimothy J McDonaldSuna Onengut-GomuscuStephen S RichColin N A PalmerJohn A McKnightMark W J StrachanAlan W PatrickJohn ChalmersRobert S LindsayJohn R PetrieSandeep ThekkepatAndrew CollierSandra MacRuryHelen M ColhounPublished in: BMC medicine (2019)
Persistence of C-peptide secretion varies widely in people clinically diagnosed as type 1 diabetes. C-peptide persistence is influenced by variants in the HLA region that are different from those determining risk of early-onset type 1 diabetes. Known risk loci for diabetes account for only a small proportion of the genetic effects on C-peptide persistence.