Determination of microRNAs associated with adverse left ventricular remodeling after myocardial infarction.
Ferhat EyüpkocaKarabekir ErcanEmrullah KiziltuncIlgin Burcu UgurluAjar KocakNilnur EyerciPublished in: Molecular and cellular biochemistry (2022)
Increasing evidence indicates that microRNA (miRNA) regulated mechanisms in myocardial healing and ventricular remodeling following acute myocardial infarction (AMI). We aim to comprehensively investigate changes of exosomal miRNA profile during the post-MI period and determine potential miRNAs associated to adverse left ventricular remodeling (ALVR). We prospectively evaluated ST-elevated MI patients with cardiac magnetic resonance imaging at the 2 weeks and 6 months after AMI (n = 10). ALVR was defined as an increase in LV end-diastolic and end-systolic volume > 13%. The blood samples were taken for miRNA measurements at the baseline, 2 and 6 weeks after AMI. In the miRNA profile assessment, 8 miRNAs were identified that were associated ALVR (miR-199a-5p, miR-23b-3p, miR-26b-5p, miR-301a-3p, miR-374a-5p, miR-423-5p, miR-483-5p and miR-652-3p). Three of them (miR-301a-3p, miR-374a-5p and miR-423-5p) differed significantly between patients with and without ALVR during follow-up period and the rest of them during the acute phase of AMI. The detection of these miRNAs, which have different role in various pathways, necessitate future mechanistic studies unravel the complex remodeling process after AMI.
Keyphrases
- left ventricular
- acute myocardial infarction
- hypertrophic cardiomyopathy
- cardiac resynchronization therapy
- heart failure
- magnetic resonance imaging
- aortic stenosis
- mitral valve
- left atrial
- gestational age
- current status
- computed tomography
- emergency department
- coronary artery disease
- mass spectrometry
- molecularly imprinted
- acute coronary syndrome
- quantum dots
- preterm birth
- ejection fraction
- clinical evaluation