Targeting Germline- and Tumor-Associated Nucleotide Excision Repair Defects in Cancer.
Sabine TopkaZoe SteinsnyderVignesh RavichandranKaitlyn TkachukYelena M KemelChaitanya BandlamudiMogens Winkel MadsenHelena FurbergOuathek OuerfelliCharles M RudinGopa IyerSteven M LipkinSemanti MukherjeeDavid B SolitMichael F BergerDean F BajorinJonathan E RosenbergBarry S TaylorElisa de StanchinaJoseph VijaiKenneth OffitPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
These findings provide novel insights into a synthetic lethal relationship between clinically observed NER gene deficiencies and sensitivity to irofulven and its potential synergistic combination with other drugs.See related commentary by Jiang and Greenberg, p. 1833.