Adipose-Derived Mesenchymal Stromal Cells Persist in Tissue-Engineered Vocal Fold Replacement in Rabbits.

Alexander N GoelBhavani S GowdaMysore S VeenaTravis L ShibaJennifer L Long

Published in: The Annals of otology, rhinology, and laryngology (2018)

The emergent tissue after implantation of a tissue-engineered outer vocal fold replacement is derived both from initially embedded adipose-derived stromal cells and infiltrating native cells. Our results suggest this tissue-engineering approach can provide a well-integrated tissue graft with prolonged cell activity for repair of severe vocal fold scars.

Keyphrases

induced apoptosis
early onset
mesenchymal stem cells
cell cycle arrest
signaling pathway
cell therapy
cell proliferation
pi k akt
platelet rich plasma