Association of Spinal Cord Atrophy and Brain Paramagnetic Rim Lesions With Progression Independent of Relapse Activity in People With MS.
Alessandro CagolPascal BenkertLester Melie-GarciaSabine A SchaedelinSelina LeberCharidimos TsagkasMuhamed BarakovicRiccardo GalbuseraPo-Jui LuMatthias WeigelEsther RuberteErnst-Wilhelm RadueÖzgür YaldizliJohanna OechteringJohannes LorscheiderMarcus D'SouzaBettina Fischer-BarnicolStefanie MüllerLutz AchtnichtsJochen VehoffGiulio DisantoOliver FindlingAndrew ChanSalmen AnkeCaroline PotClaire BridelChiara ZeccaTobias DerfussJohanna M LiebLuca RemondaFranca WagnerMaria Isabel VargasRenaud A Du PasquierPatrice H LaliveEmanuele PravatàJohannes WeberPhilippe C CattinMartina AbsintaClaudio GobbiDavid LeppertLudwig KapposJens KuhleCristina GranzieraPublished in: Neurology (2023)
Our results show that PIRA is associated with both increased spinal cord atrophy and PRL burden, and this association is evident also in patients with RRMS. These findings further point to the need to develop targeted treatment strategies for PIRA to prevent irreversible neuroaxonal loss and optimize long-term outcomes of patients with MS.