Top-down alteration of functional connectivity within the sensorimotor network in focal dystonia.
Giovanni BattistellaKristina SimonyanPublished in: Neurology (2019)
Abnormal hyperexcitability of premotor-parietal-putaminal circuitry may be explained by altered information transfer between these regions due to underlying deficient connectivity. Identification of brain regions involved in processing of sensorimotor information in preparation for movement execution suggests that complex network disruption is staged well before the dystonic behavior is produced by the primary motor cortex.