Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors.

Matthew R TrendowskiHeather E WheelerOmar El-CharifDarren R FeldmanRobert J HamiltonDavid J VaughnChunkit FungChristian KollmannsbergerLawrence H EinhornLois B TravisM Eileen Dolan

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Certain survivors are more susceptible to cisplatin-induced neurotoxicity, markedly increasing likelihood of developing numerous neuro-otological symptoms that affect quality of life. Genome-wide analysis identified genetic variation in FAM20C as a potentially important risk factor.

Keyphrases

genome wide analysis
young adults
risk factors
early onset
sleep quality