A systematic review of the literature on mechanisms of 5-nitroimidazole resistance in Trichomonas vaginalis.

Keonte J GravesJan NovakW Evan SecorPatricia J KissingerJane R SchwebkeChristina A Muzny

Published in: Parasitology (2020)

5-Nitroimidazole resistance results from differential expression of enzymes involved in energy production or antioxidant defenses, along with genetic mutations in the T. vaginalis genome. Alternative treatments outside of the 5-nitroimidazole class are needed.

Keyphrases

genome wide
copy number
gene expression