Molecular imaging of endothelial activation and mineralization in a mouse model of accelerated atherosclerosis.

Guillaume RucherLucie CameliereJihene FendriAntoine AnfrayAhmed AbbasSaïd KamelQuentin DupasNicolas DelcroixLudovic BergerAlain Manriquenull null

Published in: EJNMMI research (2019)

Preclinical molecular imaging allowed in vivo characterization of the early phase of atherosclerosis. [18F]NaF PET showed early and sustained vascular mineralization in uremic ApoE-/- mice. MPIO-αVCAM-1 MR imaging demonstrated aortic endothelial activation, predominantly in segments with vascular remodeling.

Keyphrases

mouse model
pet ct
cardiovascular disease
endothelial cells
aortic valve
computed tomography
positron emission tomography
left ventricular
heart failure
type diabetes
stem cells
magnetic resonance imaging
atrial fibrillation
metabolic syndrome
cell therapy
bone marrow
mesenchymal stem cells
aortic dissection