Combined antihypertensive effect of unripe Rubus coreanus Miq. and Dendropanax morbiferus H. Lév. Extracts in 1 kidney-1 clip hypertensive rats and spontaneously hypertensive rats.

Soyi ParkKi Hoon LeeHakjoon ChoiGoeun JangWan Seok KangEun KimJin Seok KimChang-Su NaSunoh Kim

Published in: BMC complementary medicine and therapies (2021)

Chronic HDR-2 administration may effectively improve vascular function by decreasing plasma angiotensin-converting enzyme (ACE) activity and AngII levels. HDR-2 significantly improved acetylcholine (ACh)-induced aortic endothelium-dependent relaxation and affected sodium nitroprusside (SNP)-induced endothelium-independent relaxation in SHRs.

Keyphrases

angiotensin converting enzyme
angiotensin ii
high glucose
diabetic rats
nitric oxide
drug induced
blood pressure
aortic valve
left ventricular
genome wide
heart failure
gene expression
pulmonary arterial hypertension
aortic dissection