Login / Signup

Stress-mediated convergence of splicing landscapes in male and female rock doves.

Andrew S LangSuzanne H AustinRayna M HarrisRebecca M CalisiMatthew D MacManes
Published in: BMC genomics (2020)
Our results provide vital new insight into sex-specific aspects of the stress response on the HPG axis at an unprecedented proximate level. Males and females uniquely respond to stress, yet exhibit splicing patterns suggesting a convergent, optimal splicing landscape for stress response. This information has the potential to inform evolutionary theory as well as the development of highly-specific drug targets for stress-induced reproductive dysfunction.
Keyphrases
  • stress induced
  • oxidative stress
  • genome wide
  • single cell
  • healthcare
  • dna methylation
  • gene expression
  • drug induced
  • heat stress
  • electronic health record