The aldehyde dehydrogenase cord blood potency assay excludes early apoptotic cells.

Sofia FrändbergSusann LiCecilia BoreströmJan HolgerssonLars Palmqvist

Published in: Transfusion (2018)

The ALDH assay excludes nonviable and apoptotic cells, and therefore correlates better with CFU enumeration compared to the number of viable CD34+ cells. We propose that the ALDH assay might replace the CFU-GM method in CBU potency measurements.

Keyphrases

induced apoptosis
cell cycle arrest
cell death
cord blood
high throughput
endoplasmic reticulum stress
signaling pathway
oxidative stress
pi k akt
single cell