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Pharmacokinetics of Hydroxychloroquine in Pregnancies with Rheumatic Diseases.

Stephen J BalevicThomas P GreenMegan E B ClowseAmanda M EudyLaura E SchanbergMichael Cohen-Wolkowiez
Published in: Clinical pharmacokinetics (2020)
We developed a one-compartment population-pharmacokinetic model for hydroxychloroquine in pregnant women with rheumatic disease. Estimates for serum CL were within the expected range for plasma in non-pregnant adults. Because CL and 24-h area under the curve did not change during pregnancy compared with postpartum, our modeling in this small cohort does not support adjusting hydroxychloroquine dose during pregnancy.
Keyphrases
  • pregnant women
  • pregnancy outcomes
  • rheumatoid arthritis
  • preterm birth