Immunoreactive trypsinogen levels in newborn screened infants with an inconclusive diagnosis of cystic fibrosis.

Chee Yee OoiRosie SutherlandCarlo CastellaniKatherine KeenanMargaret BolandJoe ReismanCandice BjornsonMark A ChilversRichard van WylickSteven KentApril PriceDimas Mateos-CorralDaniel HughesMelinda SolomonPeter ZuberbuhlerJanna BruskyPeter R DurieFelix RatjenTanja Gonska

Published in: BMC pediatrics (2019)

Amongst infants who tested positive on NBS for CF, there is a gradation of elevated NBS IRT concentrations. Infants with CF have higher NBS IRT levels than CRMS/CFPSID, and higher NBS IRT concentrations were present in infants with CRMS/CFSPID→CF than CRMS/CFSPID→ CRMS/CFSPID. NBS IRT concentrations, in concert with other factors, may have the potential to predict the likelihood of CF amongst infants with CRMS/CFSPID.

Keyphrases

cystic fibrosis
pseudomonas aeruginosa
lung function
climate change
human health