Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways.

Ning LiuJiao FengXiya LuZhilu YaoQing LiuYang LvYuru HanJingfan DengYingqun Zhou

Published in: Mediators of inflammation (2019)

Isorhamnetin protected against liver fibrosis by reducing ECM formation and autophagy via inhibition of TGF-β1-mediated Smad3 and p38 MAPK signaling pathways.

Keyphrases

liver fibrosis
transforming growth factor
extracellular matrix
signaling pathway
epithelial mesenchymal transition
cell death
endoplasmic reticulum stress
pi k akt
oxidative stress
induced apoptosis
cell proliferation