Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non-small Cell Lung Cancer.
Ahmed SalemRoss A LittleAyşe LatifAdam K FeatherstoneMuhammad BaburIsabel PesetSusan CheungYvonne WatsonVictoria TessymanHitesh B MistryGarry AshtonCaron BehanJulian C MatthewsMarie-Claude AsselinRobert G BristowAlan JacksonGeoffrey J M ParkerCorinne Faivre-FinnKaye J WilliamsJames P B O'ConnorPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
These findings support applying OE-MRI biomarkers to monitor hypoxia modification, to stratify patients in clinical trials of hypoxia-modifying therapies, to identify patients with hypoxic tumors that may fail treatment with immunotherapy, and to guide adaptive radiotherapy by mapping regional hypoxia.
Keyphrases
- endothelial cells
- clinical trial
- early stage
- magnetic resonance imaging
- end stage renal disease
- contrast enhanced
- ejection fraction
- high glucose
- newly diagnosed
- radiation therapy
- radiation induced
- locally advanced
- peritoneal dialysis
- prognostic factors
- diffusion weighted imaging
- computed tomography
- magnetic resonance
- patient reported
- rectal cancer
- double blind
- phase iii