Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes.
Evelyn HoutmanMargo TuerlingsH Eka D SuchimanNico LakenbergFrederique M F CornelisHailiang MeiDemiën BroekhuisRob G H H NelissenRodrigo Coutinho de AlmeidaYolande F M RamosRik J LoriesLuis J CruzIngrid MeulenbeltPublished in: Rheumatology (Oxford, England) (2022)
Treatment with the deiodinase inhibitor IOP reduced detrimental changes of injurious mechanical stress. In addition, we identified that its mode of action was likely on metabolic processes, cell proliferation and differentiation.