Characterization of Cardiac Function by Echocardiographic Global Longitudinal Strain in a Cohort of Children with Neurofibromatosis Type 1 Treated with Selumetinib.
Thomas CaiffaAntimo TessitoreAndrea MagnolatoMatilde PetzMarco BobboDaniela ChiccoBiancamaria D'Agata MottoleseAldostefano PorcariEgidio BarbiGianfranco SinagraIrene BrunoPublished in: Paediatric drugs (2022)
Patients with NF1 treated with selumetinib may experience subtle changes in systolic function identified by global longitudinal strain and not revealed by left ventricular ejection fraction. Global longitudinal strain might be useful to monitor cardiac function in this cohort of patients for the duration of therapy.
Keyphrases
- ejection fraction
- aortic stenosis
- left ventricular
- heart failure
- newly diagnosed
- signaling pathway
- blood pressure
- mitral valve
- acute myocardial infarction
- oxidative stress
- left atrial
- stem cells
- pulmonary hypertension
- chronic kidney disease
- immune response
- inflammatory response
- lps induced
- cell therapy
- patient reported outcomes
- nuclear factor
- percutaneous coronary intervention
- atrial fibrillation