Pharmacokinetic and cytokine profiles of melanoma patients with dabrafenib and trametinib-induced pyrexia.

Hannah Yejin KimJanna K DuongMaria GonzalezGeorgina V LongAlexander M MenziesHelen RizosSu Yin LimJenny LeeAlan V Boddy

Published in: Cancer chemotherapy and pharmacology (2019)

No apparent associations between pyrexia and exposure to the drugs or metabolites could be observed. Greater elevations in IL-1B and IL-6 were observed in patients with pyrexia during the first week of treatment compared to those without pyrexia.

Keyphrases

ms ms
high glucose
diabetic rats
oxidative stress
magnetic resonance
smoking cessation