Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer.
Vanessa F BonazziOlga KondrashovaDeborah SmithKatia NonesAsmerom T SengalRobert JuLeisl M PackerLambros T KoufariotisStephen H KazakoffAimee L DavidsonPriya Ramarao-MilneVanessa LakisFelicity NewellRebecca RogersClaire DaviesJames NicklinAndrea GarrettNaven ChettyLewis PerrinJohn V PearsonAnn-Marie PatchNicola WaddellPamela M PollockPublished in: Genome medicine (2022)
EC PDX models represent the four molecular subtypes of disease and can capture intra-tumor heterogeneity of the original primary tumor. PDXs of the copy number high molecular subtype showed sensitivity to PARPi; however, deeper and more durable responses will likely require combination of PARPi with other agents.