A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer.

Joseph LongoRobert J HamiltonMehdi MasoomianNajia KhurramEmily BranchardPeter J MullenMohamad ElbazKaren HerseyDianne ChadwickSangeet GhaiDavid W AndrewsEric X ChenTheodorus H Van der KwastNeil E FleshnerLinda Z Penn

Published in: Prostate cancer and prostatic diseases (2020)

Fluvastatin prior to RP achieves measurable drug concentrations in prostatic tissue and is associated with promising effects on tumor cell apoptosis. These data warrant further investigation into the anti-neoplastic effects of statins in prostate tissue.

Keyphrases

prostate cancer
radical prostatectomy
benign prostatic hyperplasia
cardiovascular disease
cell proliferation
patients undergoing
electronic health record
big data
type diabetes
study protocol
emergency department
machine learning
adverse drug
data analysis
deep learning
artificial intelligence
double blind