DNA methylation and gene expression analysis in adipose tissue to identify new loci associated with T2D development in obesity.
Paulina BacaFrancisco M Barajas-OlmosElaheh MirzaeicheshmehCarlos ZerrweckLizbeth GuilbertErnesto Carlos SánchezMarlen Flores-HuacujaRafael VillafánAngélica Martínez-HernándezHumberto Garcia-OrtizCecilia Contreras-CubasFederico Centeno-CruzLorena Orozco-OrozcoPublished in: Nutrition & diabetes (2022)
Our results revealed novel candidate genes related to T2D pathogenesis in obesity. These genes show perturbations in DNA methylation and expression profiles in patients with obesity and diabetes. Methylation profiles were able to discriminate OND from OD individuals; DNA methylation is thus a potential biomarker.
Keyphrases
- dna methylation
- genome wide
- gene expression
- insulin resistance
- type diabetes
- adipose tissue
- metabolic syndrome
- weight loss
- high fat diet induced
- weight gain
- copy number
- high fat diet
- cardiovascular disease
- glycemic control
- skeletal muscle
- transcription factor
- body mass index
- physical activity
- genome wide association study