Functional protection against cardiac diseases depends on ATP-sensitive potassium channels.
Peng YeYan-Rong ZhuYue GuDai-Min ZhangShao-Liang ChenPublished in: Journal of cellular and molecular medicine (2018)
ATP-sensitive potassium channels (KATP) channels are widely distributed in various tissues, including pancreatic beta cells, muscle tissue and brain tissue. KATP channels play an important role in cardioprotection in physiological/pathological situations. KATP channels are inhibited by an increase in the intracellular ATP concentration and are stimulated by an increase in the intracellular MgADP concentration. Activation of KATP channels decreases ischaemia/reperfusion injury, protects cardiomyocytes from heart failure, and reduces the occurrence of arrhythmias. KATP channels are involved in various signalling pathways, and their participation in protective processes is regulated by endogenous signalling molecules, such as nitric oxide and hydrogen sulphide. KATP channels may act as a new drug target to fight against cardiovascular disease in the development of related drugs in the future. This review highlights the potential mechanisms correlated with the protective role of KATP channels and their therapeutic value in cardiovascular diseases.
Keyphrases
- cardiovascular disease
- heart failure
- nitric oxide
- gene expression
- type diabetes
- left ventricular
- acute myocardial infarction
- risk assessment
- skeletal muscle
- metabolic syndrome
- cell death
- oxidative stress
- induced apoptosis
- white matter
- reactive oxygen species
- cell proliferation
- brain injury
- climate change
- endoplasmic reticulum stress
- signaling pathway
- high glucose