Monoclonal B-cell Lymphocytosis - a review of diagnostic criteria, biology, natural history, and clinical management.
Catherine TangYandong ShenAsha SoosapillaStephen P MulliganPublished in: Leukemia & lymphoma (2022)
Since first described almost two decades ago, there has been significant evolution in our definition and understanding of the biology and implications of monoclonal B-cell lymphocytosis (MBL). This review provides an overview of the definition, classification, biology, and natural history of MBL, mainly focused on the dominant CLL-like phenotype form of MBL. The increasingly recognized implications of MBL with respect to immune dysfunction are discussed, particularly in view of the COVID-19 pandemic, along with management recommendations for MBL in the clinic.