Expression and Activity of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Distal Lung Epithelial Cells In Vitro.

Sabrina NickelMohammed Ali SeloJuliane FallackCaoimhe G ClerkinHanno HuwerNicole Schneider-DaumClaus-Michael LehrCarsten Ehrhardt

Published in: Pharmaceutical research (2017)

BCRP is differently expressed in AT2 and AT1-like cells with lower abundance and activity in the latter ones. Nuclear BCRP might play a transcriptional role in distal lung epithelium. In NCI-H441 cells, BCRP is expressed in apical cell membranes and its activity is consistent with the localisation pattern.

Keyphrases

endothelial cells
induced apoptosis
minimally invasive
gene expression
stem cells
binding protein
transcription factor
oxidative stress
cell therapy
bone marrow
cell death
cell cycle arrest
mesenchymal stem cells
signaling pathway
amino acid
heat shock
long non coding rna
small molecule
heat stress