Persistent Systemic Microbial Translocation, Inflammation, and Intestinal Damage During Clostridioides difficile Infection.

Alessandra OlivaLucia AversanoMassimiliano De AngelisMaria Teresa MascellinoMaria Claudia MieleSergio MorelliRiccardo BattagliaJessica IeraGiovanni BrunoEnrico Stefano CorazziariMaria Rosa CiardiMario VendittiClaudio Maria MastroianniVincenzo Vullo

Published in: Open forum infectious diseases (2019)

CDI is associated with high levels of microbial translocation, inflammation, and intestinal damage, which are still present at clinical resolution of CDI. The role of residual mucosal perturbation and persistence of intestinal cell damage in the development of n-BSI following CDI, as well as the possible effect of FMT in the restoration of mucosal integrity, should be further investigated.

Keyphrases

oxidative stress
microbial community
clostridium difficile
single cell
ulcerative colitis
cell therapy
single molecule
mass spectrometry
high resolution
atomic force microscopy