Diagnosis of acute myocardial infarction: highlighting cardiac troponins as vital biomarkers.
Ali PouraliYadollah OmidiPublished in: BioImpacts : BI (2022)
The molecular marker, cardiac troponin (cTn) is a complex protein that is attached to tropomyosin on the actin filament. It is an essential biomolecule in terms of the calcium-mediated regulation of the contractile apparatus in myofibrils, the release of which is an indication of the dysfunction of cardiomyocytes and hence the initiation of ischemic phenomena in the heart tissue. Fast and accurate analysis of cTn may help the diagnosis and management of acute myocardial infarction (AMI), for which electrochemical biosensors and microfluidics devices can be of great benefit. This editorial aims to highlight the importance of cTn as vital biomarkers in AMI diagnosis.
Keyphrases
- acute myocardial infarction
- left ventricular
- percutaneous coronary intervention
- heart failure
- gold nanoparticles
- skeletal muscle
- oxidative stress
- label free
- acute coronary syndrome
- atrial fibrillation
- ionic liquid
- smooth muscle
- small molecule
- single molecule
- mass spectrometry
- molecularly imprinted
- protein protein
- binding protein
- cell migration