Influence of methylxanthines isolated from Bancha green tea on the pharmacokinetics of sildenafil in rats.

Maya P Radeva-Ilieva Stanila S Stoeva Nadezhda R Hvarchanova Iliya J Slavov Kaloyan D Georgiev

Published in: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences (2022)

Drug-herb interactions were observed when sildenafil was co-administered with Bancha methylxanthines in rats. Further in vivo studies about the potential drug interactions between sildenafil and methylxanthines, especially caffeine, are needed to clarify mechanisms underlying the observed changes in sildenafil pharmacokinetics.

Keyphrases

pulmonary hypertension
pulmonary arterial hypertension
emergency department
drug induced
risk assessment
case control