Emergence of clonal chromosomal alterations during the mesenchymal stromal cell cultivation.

Tamara BorgonovoMaria Marlene SolarewiczIsadora May VazDebora DagaCarmen Lúcia Kuniyoshi RebelattoAlexandra Cristina SenegagliaEnilze RibeiroIglenir João CavalliPaulo Slud Brofman

Published in: Molecular cytogenetics (2015)

Although there is controversy about the use of cells with cytogenetic abnormality for therapy, because their tumorigenic doubtful potential, we decided against the use of these cells forregenerative medicine.

Keyphrases

induced apoptosis
cell cycle arrest
bone marrow
single cell
oxidative stress
gene expression
mesenchymal stem cells