Sex differences in the evolution of left ventricle remodeling in rats with severe volume overload.

Elisabeth Walsh-WilkinsonMarie-Claude DroletMarie ArsenaultJacques Couët

Published in: BMC cardiovascular disorders (2020)

AR resulted in more LV dilation and quicker wall thickening in female AR rats compared to males. Global circumferential strain was negatively modulated in AR females but not in males. AR also seemed to lead to a more spherical LV shape in females whereas; it kept mostly an ellipsoid shape in males. This can influence validity of mass estimation of the dilated LV in females by echocardiography.

Keyphrases

pulmonary hypertension
computed tomography
left ventricular
pulmonary artery
mitral valve
early onset
drug induced