Silibinin solubilization: combined effect of co-solvency and inclusion complex formation.
Azam DehghanSaeed GhanbarzadehMajid GhiassMohammad ImaniPublished in: Drug development and industrial pharmacy (2024)
SLB solubility in a buffered solution supplemented by ethanol co-solvent and HP-β-CD complexing agent is a function of free drug present in the semi-aqueous media, the drug-ligand binary complex, and the drug/ligand/co-solvent ternary complex.