The reference liver-CYP450 and UGT enzymes in healthy donor and metastatic livers: the impact of genotype.

Mateusz KurzawskiSylwia Szeląg-PieniekJoanna Łapczuk-RomańskaMaciej WrzesińskiStefan OswaldMarek Droździk

Published in: Pharmacological reports : PR (2021)

The selection of a control group for the study on drug-metabolizing enzymes (e.g. in pathological states) may possibly affect its conclusions on differences in mRNA and protein content. Genotyping for common functional variants of CYP450 enzymes should be performed in all studies on drug-metabolizing enzymes.

Keyphrases

squamous cell carcinoma
small cell lung cancer
genome wide
adverse drug
high throughput
gene expression
dna methylation
protein protein