Pangenome and genomic signatures linked to the dominance of the lineage-4 of Mycobacterium tuberculosis isolated from extrapulmonary tuberculosis patients in western Ethiopia.
Basha ChekesaHarinder SinghNorberto Gonzalez-JuarbeSanjay VasheeRosana Wiscovitch-RussoChristopher L DupontMusse GirmaOudessa Kerro DegoBalako GumiGobena AmeniPublished in: PloS one (2024)
Apart from host and environmental factors, the sublineage of L4 employs distinct virulence factors for successful dissemination in western Ethiopia. Given that the functions of these newly identified genes are not well understood, it is advisable to experimentally validate their roles, particularly in the successful transmission of specific L4 sublineages over others.
Keyphrases
- mycobacterium tuberculosis
- end stage renal disease
- ejection fraction
- south africa
- newly diagnosed
- chronic kidney disease
- escherichia coli
- pseudomonas aeruginosa
- pulmonary tuberculosis
- peritoneal dialysis
- patient reported outcomes
- emergency department
- gene expression
- cystic fibrosis
- biofilm formation
- dna methylation
- human immunodeficiency virus
- transcription factor
- bioinformatics analysis
- electronic health record
- cell fate