The brain-penetrant cell-cycle inhibitor p28 sensitizes brain metastases to DNA-damaging agents.
Sunam ManderGregory S GormanLori U CowardKonstantin ChristovAlbert GreenTapas K Das GuptaTohru YamadaPublished in: Neuro-oncology advances (2023)
The cell-cycle inhibitor p28 can cross the BBB localize to tumor lesions in the brain and enhance the inhibitory effects of DNA-damaging agents on BMs, suggesting the potential therapeutic benefits of this molecule in BMs.
Keyphrases
- cell cycle
- brain metastases
- cell proliferation
- circulating tumor
- resting state
- white matter
- small cell lung cancer
- cell free
- single molecule
- functional connectivity
- blood brain barrier
- cerebral ischemia
- induced apoptosis
- multiple sclerosis
- oxidative stress
- brain injury
- subarachnoid hemorrhage
- circulating tumor cells
- endoplasmic reticulum stress