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Double strand DNA breaks in sperm: the bad guy in the crowd.

Juan G AlvarezAgustin García-PeiróAlberto BarrosLuís FerrazMário SousaDenny Sakkas
Published in: Journal of assisted reproduction and genetics (2023)
Double-strand DNA breaks in sperm provide a greater stress on repair mechanisms and challenge the threshold of repair in oocytes. It is therefore imperative that we improve our understanding and diagnostic ability of sperm DNA, and in particular, how double-strand DNA breaks originate and how an oocyte or embryo is able to deal with them.
Keyphrases
  • circulating tumor
  • cell free
  • single molecule
  • nucleic acid
  • circulating tumor cells