Investigating the Vascular Toxicity Outcomes of the Irreversible Proteasome Inhibitor Carfilzomib.
Panagiotis EfentakisHendrik DoerschmannClaudius WitzlerSvenja SiemerPanagiota-Efstathia NikolaouEfstathios KastritisRoland StauberMeletios Athanasios DimopoulosPhilip WenzelIoanna AndreadouEvangelos TerposPublished in: International journal of molecular sciences (2020)
Carfilzomib induces a transient vascular impairment and oxidative burst. Cfz+Met increased vascular contractility and synergistically induced autophagy in all settings. Therefore, carfilzomib cannot be accredited for a permanent vascular dysfunction, while Cfz+Met exert vasoprotective potency.