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The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1α translation.

Liang-Yan ChenLian WangYue-Xiang RenZheng PangYao LiuXiao-Dong SunJian TuZheng ZhiYan QinLi-Na SunJian-Ming Li
Published in: Molecular cancer (2020)
Our findings uncover a key mechanism for circ-Erbin mediated HIF-1α activation by miR-125a-5p-5p/miR-138-5p/4EBP-1 axis and circ-ERBIN is a potential target for CRC treatment.
Keyphrases
  • endothelial cells
  • risk assessment
  • replacement therapy