Ovulatory signal-triggered chromatin remodeling in ovarian granulosa cells by HDAC2 phosphorylation activation-mediated histone deacetylation.

Jiamin JinPeipei RenXiang LiYinyi ZhangWeijie YangYerong MaMengru LaiChao YuSong-Ying Zhang Yin-Li Zhang

Published in: Epigenetics & chromatin (2023)

This study demonstrates that the ovulatory signal erases histone acetylation through activation of CK2α-mediated HDAC2 phosphorylation in granulosa cells, which is an essential prerequisite for subsequent successful ovulation.

Keyphrases

induced apoptosis
cell cycle arrest
polycystic ovary syndrome
dna methylation
histone deacetylase
gene expression
type diabetes
dna damage
cell death
endoplasmic reticulum stress
signaling pathway
metabolic syndrome