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In vivo evaluation of a microtubule PET ligand, [11C]MPC-6827, in mice following chronic alcohol consumption.

J S Dileep KumarAndrei MolotkovMichael C SallingPatrick CarberryJaya PrabhakaranJohn CastrillonAkiva Mintz
Published in: Pharmacological reports : PR (2021)
This pilot study indicates a trend of loss of microtubule binding in whole brain and prefrontal cortex of chronic alcohol administered mice brain compared to control mice, but no loss in heart or liver. These results indicate the potential of [11C]MPC-6827 as a PET ligand for further in vivo imaging investigations of AUD in human.
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