In vivo evaluation of a microtubule PET ligand, [11C]MPC-6827, in mice following chronic alcohol consumption.
J S Dileep KumarAndrei MolotkovMichael C SallingPatrick CarberryJaya PrabhakaranJohn CastrillonAkiva MintzPublished in: Pharmacological reports : PR (2021)
This pilot study indicates a trend of loss of microtubule binding in whole brain and prefrontal cortex of chronic alcohol administered mice brain compared to control mice, but no loss in heart or liver. These results indicate the potential of [11C]MPC-6827 as a PET ligand for further in vivo imaging investigations of AUD in human.
Keyphrases
- alcohol consumption
- high fat diet induced
- prefrontal cortex
- computed tomography
- endothelial cells
- resting state
- white matter
- positron emission tomography
- pet ct
- high resolution
- functional connectivity
- multiple sclerosis
- wild type
- cerebral ischemia
- insulin resistance
- risk assessment
- blood brain barrier
- photodynamic therapy
- brain injury
- climate change
- induced pluripotent stem cells
- fluorescence imaging