Image-based analysis of skeletal muscle mass predicts cisplatin dose-limiting toxicity in patients with locally advanced head and neck cancer.

Najiba ChargiFereshta BashiriAnne W WendrichErnst J SmidPim A de JongAlwin D R HuitemaLot A DevrieseRemco de Bree

Published in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2022)

Low SMM was associated with an increased risk of DLT. Trials are needed to investigate cisplatin dosing with consideration of SMM rather than solely BSA.

Keyphrases

skeletal muscle
locally advanced
rectal cancer
squamous cell carcinoma
neoadjuvant chemotherapy
insulin resistance
deep learning
oxidative stress
radiation therapy
type diabetes
machine learning
open label