Mechano-Informed Biomimetic Polymer Scaffolds by Incorporating Self-Powered Zinc Oxide Nanogenerators Enhance Motor Recovery and Neural Function.
Yun QianYuan ChengJialin SongYang XuWei-En YuanCunyi FanXianyou ZhengPublished in: Small (Weinheim an der Bergstrasse, Germany) (2020)
Piezoelectric materials can produce electrical power from the mechanical stimulation and thus, they may accelerate electroactive tissue healing as a promising treatment for traumatic peripheral nerve injuries. In this study, a piezoelectric zinc oxide nanogenerator scaffold is manufactured by 3D injectable multilayer biofabrication. The piezoelectric polymeric scaffold displays desirable mechanical and physical characteristics, such as aligned porosity, high elasticity, scaffold stiffness, surface energy, and excellent shear behavior. In addition, its biocompatibility supplies Schwann cells with an adhesive, proliferative, and angiogenic interface, as is reflected by higher expression of functional proteins including nerve growth factor (NGF) and vascular endothelial growth factor (VEGF). In vivo mechanical stimuli by treadmill practice contribute to the comprehensive reparative therapy. The piezoelectric conduit accelerates nerve conducting velocity, promotes axonal remyelination, and restores motor function by recovering endplate muscles. Moreover, the piezoelectric nanogenerator scaffold creates biomimetic electrically conductive microenvironment without causing noticeable toxicity to functioning organs and improves peripheral nerve restoration by the multifunctional characteristics. Therefore, the mechano-informed biomimetic piezoelectric scaffold may have enormous potential in the neuroengineering for regenerative medicine.
Keyphrases
- tissue engineering
- peripheral nerve
- growth factor
- vascular endothelial growth factor
- spinal cord injury
- drug delivery
- oxide nanoparticles
- induced apoptosis
- primary care
- mental health
- stem cells
- physical activity
- binding protein
- endoplasmic reticulum stress
- risk assessment
- gold nanoparticles
- cell proliferation
- quality improvement
- long non coding rna
- combination therapy
- signaling pathway