The dynamic association between Frailty, CD4 and CD4/CD8 ratio in people aging with HIV.

Giovanni GuaraldiStefano ZonaAna Rita SilvaMarianna MenozziGiovanni DolciJovana MilicFederica CarliCristina Mussini

Published in: PloS one (2019)

Frailty in PLWH is inversely associated with both immune-activation, depicted by CD4/CD8 ratio and immune-deficit depicted by CD4 count. The first association shows a linear shape while the second shows a hook-shape with a turning point at 900 cells. Above this cut off level CD4 do not represent a significant risk factor for frailty.

Keyphrases

induced apoptosis
nk cells
community dwelling
antiretroviral therapy
hiv positive
hiv infected
human immunodeficiency virus
hepatitis c virus
hiv testing
hiv aids
men who have sex with men
south africa
pi k akt