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Triiodo-L-thyronine (T3) downregulates Npr1 gene (coding for natriuretic peptide receptor-A) transcription in H9c2 cells: involvement of β-AR-ROS signaling.

Gopinath NagarajElangovan Vellaichamy
Published in: Endocrine (2024)
Our result suggest that down regulation of Npr1 gene transcription is critically involved in T3- induced hypertrophic growth in H9c2 cells, and identifies the cross-talk between T3-β-AR-ROS and NPR-A signaling.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • genome wide
  • cell death
  • dna damage
  • transcription factor
  • copy number
  • endoplasmic reticulum stress
  • reactive oxygen species
  • signaling pathway
  • cell proliferation
  • endothelial cells