Revisiting atenolol as a low passive permeability marker.

Xiaomei ChenTim SlättengrenElizabeth C M de LangeDavid E SmithMargareta Hammarlund-Udenaes

Published in: Fluids and barriers of the CNS (2017)

It is concluded, based on Kp,uu,brain being much smaller than unity, that S-atenolol is actively effluxed at the BBB, indicating the need to re-consider S-atenolol as a model drug for passive permeability studies of BBB transport or intestinal absorption.

Keyphrases

blood brain barrier
endothelial cells
cerebral ischemia
white matter
resting state
multiple sclerosis
drug induced