Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia.

Valéria Cristina Sandrim Marcelo Rizzatti Luizon Eliane Pilan Mayara Caldeira-Dias Fernanda Borchers Coeli-Lacchini Georgia Kors Iuly Berndt Riccardo Lacchini Ricardo de Carvalho Cavalli

Published in: Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia (2020)

We found interactions between the HMOX-1 and NOS3 genes and responsiveness to methyldopa and that the HMOX1 polymorphism affects the levels of enzyme HO-1 in responsiveness to methyldopa and to total antihypertensive therapy. These data suggest impact of the combination of these two polymorphisms on antihypertensive responsiveness in PE.

Keyphrases

blood pressure
hypertensive patients
nitric oxide synthase
genome wide
early onset
emergency department
electronic health record
gene expression
machine learning
mesenchymal stem cells
cell proliferation
cell therapy
adverse drug
deep learning
smoking cessation