Inflammatory cells infiltrate and angiogenesis in locally advanced and metastatic cholangiocarcinoma.
Roberto TammaTiziana AnneseSimona RuggieriOronzo BrunettiVito LongoEliano CascardiMauro Giuseppe MastropasquaEugenio MaioranoNicola SilvestrisDomenico RibattiPublished in: European journal of clinical investigation (2019)
In locally advanced CCA patients, there is a significant increase of immune cell infiltrate constituted by CD8+ and CD4+ lymphocytes, macrophages and mast cells as compared to the metastatic ones. This alteration in the tumour microenvironment infiltrate is related to a significant increased MVD in localized CCA lesions compared with the metastatic ones. Moreover, we observed a negative correlation between MVD and CD8+ , CD4+ cells in localized CCA patients.
Keyphrases
- squamous cell carcinoma
- end stage renal disease
- locally advanced
- small cell lung cancer
- induced apoptosis
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- stem cells
- peritoneal dialysis
- neoadjuvant chemotherapy
- cell cycle arrest
- oxidative stress
- clinical trial
- radiation therapy
- patient reported outcomes
- signaling pathway
- phase ii study
- endoplasmic reticulum stress
- patient reported
- double blind