The Proteomic Landscape of Pancreatic Ductal Adenocarcinoma Liver Metastases Identifies Molecular Subtypes and Associations with Clinical Response.

Henry C-H LawDragana LagundžinEmalie J ClementFangfang QiaoZachary S WagnerKimiko L KriegerDiane Costanzo-GarveyThomas C CaffreyJean L GremDominick J DiMaioPaul M GrandgenettLeah M Cook Kurt W FisherFang YuMichael A HollingsworthNicholas T Woods

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

These data demonstrate that proteomic analysis of clinical PDAC liver metastases can identify molecular signatures unique to disease subtypes and point to opportunities for therapeutic development to improve the treatment of PDAC.

Keyphrases

liver metastases
genome wide
single molecule
gene expression
machine learning
big data
replacement therapy
deep learning