Dibenzazepine promotes cochlear supporting cell proliferation and hair cell regeneration in neonatal mice.
Jingfang WuXinran DongWen LiLiping ZhaoLi ZhouShan SunHuawei LiPublished in: Cell proliferation (2020)
Our study demonstrates that DBZ can significantly promote SC proliferation and increase the number of mitotically regenerated HCs with relatively mature stereocilia bundles in the neonatal mouse cochlea by inhibiting Notch signalling and activating Wnt signalling, suggesting the DBZ might be a new therapeutic target for stimulating HC regeneration.